Publications

  • Karimian Shamsabadi, M., Jia, X. (2023) Development of A Fluorescent Polarization Assay for High-Throughput Screening of Inhibitors against HIV-1 Nef-Mediated CD4 Downregulation. Under revision.
  • Karimian Shamsabadi, M., Jia, X. (2023) Development of A Fluorescent Polarization Assay for High-Throughput Screening of Inhibitors against HIV-1 Nef-Mediated MHC-I Downregulation. Under revision.
  • Kwon, Y., Kaake, R.M., Echeverria, I., Suarez, M., Karimian Shamshabadi, K., Stoneham, C.A., Ramirez, P.W., Kress, J., Singh, R., Sali, A., Krogan, N., Guatelli, J., Jia, X. (2020) Structural Basis of CD4 Downregulation by HIV-1 Nef. Nature Structural & Molecular Biology, 27, 822–828. (A Behind The Paper blog introducing this publication has been posted at the Nature Microbiology Community; The work has also been featured in a News & Views commentary written by experts in the field)
  • Stoneham, C.A.*, Ramirez, P.W.*, Singh, R., Suarez, M., Debray, A., Lim, C., Jia, X., Xiong, Y., and Guatelli, J. (2019) A Conserved Acidic-Cluster Motif in SERINC5 Confers Partial Resistance to Antagonism by HIV-1 Nef. Journal of Virology, e01554-19.
  • Singh, R., Stoneham, C., Lim, C., Jia, X., Guenaga, J., Wyatt, R., Wertheim, J.O., Xiong, Y., Guatelli, J., (2018) Phosphoserine acidic cluster motifs bind distinct basic regions on the μ subunits of clathrin adaptor protein complexes. Journal of Biological Chemistry, 293, 15678-15690.
  • Stoneham, C.A., Singh, R., Jia, X., Xiong, Y., and Guatelli, J. (2017) Endocytic Activity of HIV-1 Vpu: Phosphoserine-dependent Interactions with Clathrin Adaptors. Traffic, 18, 545-561.
  • Mahiti, M., Toyoda, M., Jia, X., Kuang, X.T., Mwimanzi, F., Mwimanzi, P., Walker, B.D., Xiong, Y., Brumme, Z.L., Brockman, M.A., Ueno, T. (2016) Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences. MBio e01516-15.
  • Jia, X., Zhao, Q., Xiong, Y. (2015) HIV Suppression by Host Restriction Factors and Viral Immune Evasion. Current Opinion in Structural Biology 31:106–114.
  • Yapici, I., Lee, K., Berbasova, T., Nosrati, M., Jia, X., Vasileiou, C., Wang, W., Santos, E.M., Geiger, J.H., Borhan, B. (2015) “Turn-On” Protein Fluorescence: In Situ Formation of Cyanine Dyes, Am. Chem. Soc. 137, 1073-1080.
  • Alazami, A.M., ……, Jia, X. et al. (2015). Accelerating Novel Candidate Gene Discovery in Neurogenetic Disorders Through Whole-Exome Sequencing of Prescreened Multiplex Consanguineous Families. Cell Reports 10, 148-161.
  • Jia, X.*, Weber, E.*, Tokarev, A., Lewinski, M., Rizk, M., Suarez, M., Guatelli, J.#, Xiong, Y.# (2014) Structural Basis of HIV-1 Vpu-Mediated BST2 antagonism via Hijacking of the Clathrin Adaptor Protein Complex 1, eLife 2014;3:e02362.
  • Patel, N., Khan, A.O., Mansour, A., Mohamed, J.Y., Al-Assiri, A., Haddad, R., Jia, X., Xiong, Y., Megarbane, A., Traboulsi, E.I., Alkuraya, F.S. (2014) Mutations in ASPH Cause Facial Dysmorphism, Lens Dislocation, Anterior-Segment Abnormalities, and Spontaneous Filtering Blebs, or Traboulsi Syndrome, J. Hum. Genet. 94(5):755-759.
  • Jia, X., Singh, R.K., Homann, S., Yang, H., Guatelli, J., Xiong, Y. (2012) Structural Basis of Evasion of Cellular Adaptive Immunity by HIV-1 Nef, Struct. Mol. Biol. 19(7), 701-706. Featured article.
  • Lee, K., Berbasova, T., Vasileiou, C., Jia, X., Wang, W., Choi, Y., Nossoni, F., Geiger, J.H., Borhan, B. (2012) Probing Wavelength Regulation with an Engineered Rhodopsin Mimic and a C15-Retinal Analogue, ChemPlusChem 16, 273-276.
  • Cnudde, S.E., Prorok, M., Jia, X., Castellino, F.J., Geiger, J.H. (2011) The Crystal Structure of the Calcium-Bound con-G[Q6A] Peptide Reveals a Novel Metal-Dependent Helical Trimer, Biol. Inorg. Chem. 77, 257-266.
  • Yang, H.*, Wang, J.*, Jia, X., McNatt, M. W., Zang, T., Pan, B., Meng, W., Wang, H., Bieniasz, P. D., Xiong, Y. (2010) Structural Insight into the Mechanisms of Enveloped Virus Tethering by Tetherin, Natl. Acad. Sci. 107(43), 18428-18432.
  • Sheng, F., Jia, X., Yep, A., Preiss, J., and Geiger, J. H. (2009) The Crystal Structure of the Open and Catalytically Competent Closed Conformation of Escherichia coli Glycogen Synthase, Biol. Chem. 284(26), 17796-17807.
  • Vasileiou, C., Wang, W., Jia, X., Lee, K., Watson, C., Geiger, J.H., and Borhan, B. (2009) Elucidating the Exact Role of Engineered CRABPII Residues for the Formation of a Retinal Protonated Schiff Base, Proteins: Structure, Function and Bioinformatics, 77(4), 812-822.
  • Vaezeslami, S., Jia, X., Vasileiou, C., Borhan, B., and Geiger, J. H. (2008) Structural Analysis of Site-Directed Mutants of Cellular Retinoic Acid Binding Protein II Addresses the Relationship between Structural Integrity and Ligand Binding, Acta Crystallogr. D64, 1228-1239.